Pharmaceutics: The Science of Dosage Form Design by Aulton

Pharmaceutics: The Science of Dosage Form Design by Aulton


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Physical Pharmacy

Physical Pharmacy


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Modern Pharmaceutics by banker Rhodes

Modern Pharmaceutics by banker Rhodes


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HPLC: A Practical Guide (Chromatography Monographs)

HPLC: A Practical Guide (Chromatography Monographs)
This book answers two basic questions regarding chromatography; it focuses on how compounds can high-performance liquid be separated and on why particular compounds are separated by liquid chromatographic methods. It consists of six chapters: Basic Concepts of HPLC; Instrumentation: Preparation, Testing and Selectivity of Stationary Phase Materials; Selection of the Eluent; Separation Based on an Improved Column Efficiency; Influence of
Physical Chemistry on Separations in Liquid Chromatography. The focus is on the basic considerations in liquid chromatography rather than the applications but there are also sections on trouble-shooting. The book is concerned mainly with the selection of a packing material and the preparation of the eluent. Theoretical optimization is demonstrated using the chromatography of simple chemicals, to aid the understanding of liquid chromatography by graduate students. The examples given go beyond what can be found in general textbooks on liquid chromatography. The separations can be easily understood from the differences in properties of familiar compounds known to undergraduate students.
The chromatographic separations described are based on solubility using molecular properties. The selection of chromatographic mode and column is analysed using solubility parameters. The separation factor cc is described in detail by physical and chemical parameters. Discussion of instrumentation focuses on high-efficiency operation and is concerned with degassing, the time constant, flow cell design, connectors and trouble-shooting. Packing materials and their synthesis and surface modification, liquid chromatographic analysis of surface activity and the evaluation of packed columns, including the measurement of void volume, are also considered.

Introduction to Modern Liquid Chromatography-2 Ed.

Introduction to Modern Liquid Chromatography-2 Ed.
This Second Edition incorporates the latest developments in the practical application of LC. Covers the basic of LC, the six LC methods and their applications, and various specialized areas. Provides material for in-depth comprehension of how HPLC is performed, what the necessary materials are, and possible applications. Offers thorough treatment of such areas as quantitative and qualitative analysis by HPLC, preparative scale separations, gradient elution and column-switching, sample pretreatment and reaction detectors, automated systems for high-volume testing and/or samples requiring pretreatment, troubleshooting and sample artifacts, and selection and development of LC method for a particular applications

Sample Preparation in Chromatography

Sample Preparation in Chromatography
Sample preparation is an essential step in many analyses. This book approaches the topic of sample preparation in chromatography in a methodical way, viewing it as a logical connection between sample collection and analytical chromatography. Providing a guide for choosing the appropriate sample preparation for a given analysis, this book describes various ways to process the sample, explaining the principle, discussing the advantages and disadvantages, describing the applicability to different types of samples, and showing the fitness to specific chromatographic determinations.

Absorption and Drug Development: Solubility, Permeability, and Charge State

Absorption and Drug Development: Solubility, Permeability, and Charge State

Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:

• Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.
• Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.

A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bioanalysis and Drug Metabolism is a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such ashigh performance liquid chromatography, protein binding, pharmacokinetics and drugdrug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

Methods in Enzymology, Volume 391: Liposomes, Part E

Methods in Enzymology, Volume 391: Liposomes, Part E

Liposomes are cellular structures made up of lipid molecules. Important as a cellular model in the study of basic biology, liposomes are also used in clinical applications such as drug delivery and virus studies. Liposomes Part E is a continuation of previous MIE Liposome volumes A, B, C and D.
* One of the most highly respected publications in the field of biochemistry since 1955
* Frequently consulted, and praised by researchers and reviewers alike
* Truly an essential publication for anyone in any field of the life sciences

Filtration and Purification in the Biopharmaceutical Industry, Second Edition

Filtration and Purification in the Biopharmaceutical Industry, Second Edition

Expanded to include extensive new material on the critical role of purification and detailing the significant advances in filtration science and technology, this Second Edition of a classic reference provides state-of-the-science information on all aspects of filtration and purification, including current methods, processes, technologies, equipment, and the latest industry standards and regulatory requirements for the pharmaceutical and biopharmaceutical industries.

Practical HPLC Method Development, 2nd Edition

Practical HPLC Method Development, 2nd Edition

This revision brings the reader completely up to date on the evolving methods associated with increasingly more complex sample types analyzed using high-performance liquid chromatography, or HPLC. Thebook also incorporates updated discussions of many of the fundamental components of HPLC systems and practical issues associated with the use of this analytical method. This edition includes new or expanded treatments of sample preparation, computer assisted method development, as well as biochemical samples, and chiral separations.